By By C.K. Cain
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Of particular 6 7 - C OCH3 i n t e r e s t in their p a p e r s is the r e p o r t of OCH3 the marked influence on pharmacological activity of changes in position and/ o r IV nature of the afkoxy groups. B o i s s i e r and c o - w o r l ~ e r sstated ~ ~ that tests in animals show the compound to be a sedative but not a hypnotic even a t toxic doses. r / \ 32 Sect. I - CNS Agents B i e l , Ed. Metabolic studies of the optical antipodes of glutethimide (V) (Doriden@)by Keberle, Riess and HoffmannZ3 a r e of especial interest since the authors showed stereospecific metabolism in dogs.
R. Kahn, J. T h o r a c . 901 (1965). Cardiov. Surg. 2, (57) J. DeCastro, P. Mundeleer and T. Bauduin, S u r v e y of A n e s t h e s i ology (3, 348 (1965). (58) C. W . Gorodetzky and W. R. Martin, Clin. P h a r m a c o l . T h e r a p . 6, 731 (1965). (59) U. Aubry, R. Denis, M. Keeri-Szanto and M. P a r e n t , Canad. Anaesth. SOC. J. l2, 510 (1965). (60) M. G e m p e r l e and J. C. Buhler, Schweiz. Med. Wochschr. 158 (1965). (61) A. B. Dobkin and P . K . Y . Lee, Canad. Anaesth. SOC. J. l2, 34 (1965).
H. Maddox, E. F. Oodefroi and R. F. Parcell. J. Med. , 8_, 230 (1965). li2. A. J. Friedhoff and E. Vanwinkle. Nature, 897 (1962). 113. R. E. Bourdillon, C. A. Clarke, A. P. Ridges, P. M. Sheppard, P. Harper and S. A. Leslie, Nature, @. 453 (1965). 114. Editorial, Brit. Med. , 1966, I, 119. 115. A. J. Friedhoff and E. Vanwinkle, Nature, 1pe. 1271 (19631. 178 (1962). 116. A. M. Ernest, Nature, 117. R. Michaux and W. 0 . , 1, 175 (1963). 118. J. H. Biel. in "Advances in Chemistry Series," No. 45, ed.
Annual Reports Medicinal Chemistry Volume 1 by By C.K. Cain