By Jonathan I. Epstein
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Additional info for Bladder Biopsy Interpretation
Prog Clin Biol Res 1984;162A:55–74. 14. Cheng L, Cheville JC, Neumann RM, et al. Natural history of urothelial dysplasia of the bladder. Am J Surg Pathol 1999;23:443–447. 15. Cheng L, Cheville JC, Neumann RM, et al. Flat intraurothelial lesions of the urinary bladder. Cancer 2000;88:625–631. 16. Levi AW, Potter SR, Schoenberg MP, et al. Clinical significance of denuded urothelium in bladder biopsy. J Urol 2001;166:457–460. 17. Amin MB, Murphy WM, Reuter VE, et al. Controversies in the pathology of transitional cell carcinoma of the urinary bladder.
In most cases at cystoscopy, a focal elevated lesion is identified that is variably described as “bleblike,” “papillary,” “raised,” “sessile,” or “frondular” (2). Histologically, papillary hyperplasia consists of undulating urothelium arranged into mucosal narrow papillary folds of varying heights (Fig. 1) (efigs 180–190). Both the urothelium within papillary hyperplasia and the adjacent flat mucosa are often thicker than normal. In addition to the diagnostic mucosal folds, in some cases there are also tent-shaped, somewhat broader folds that lack the edema and inflammation typical of polypoid cystitis.
An objective morphologic parameter to aid in the diagnosis of flat urothelial carcinoma in situ. Hum Pathol 2001;32:997–1002. 4. Tannenbaum M. Inflammatory proliferative lesion of the urinary bladder: squamous metaplasia. Urology 1976;7:428–429. 5. McKenney JK, Desai S, Cohen C, et al. Discriminatory immunohistochemical staining of urothelial carcinoma in situ and non-neoplastic urothelium. An analysis of cytokeratin 20, p53, and CD44 antigens. Am J Surg Pathol 2001;25:1074–1078. 6. Amin MB, Young RH.
Bladder Biopsy Interpretation by Jonathan I. Epstein