Download PDF by Michelangelo Gruttadauria: Catalytic Methods in Asymmetric Synthesis: Advanced

By Michelangelo Gruttadauria

ISBN-10: 0470641363

ISBN-13: 9780470641361

This booklet covers advances within the tools of catalytic uneven synthesis and their functions. insurance strikes from new fabrics and applied sciences to homogeneous metal-free catalysts and homogeneous steel catalysts. The purposes of a number of methodologies for the synthesis of biologically lively molecules are mentioned. half I addresses fresh advances in new fabrics and applied sciences similar to supported catalysts, helps, self-supported catalysts, chiral ionic drinks, supercritical fluids, movement reactors and microwaves with regards to uneven catalysis. half II covers advances and milestones in organocatalytic, enzymatic and metal-based mediated uneven synthesis, together with functions for the synthesis of biologically energetic molecules. Written by means of prime overseas specialists, this publication involves sixteen chapters with 2000 References and illustrations of 560 schemes and figures.

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The copolymer 47 (Fig. 20) in a 10 mol% loading provided 96% yield with 90% ee for the same reaction. In the recycling assays, consistent 90% ee was obtained during five cycles. However, the reaction time required to achieve high conversions increased gradually in each cycle [87]. Ligand 46 was studied in copper-catalyzed Mukaiyama aldol reactions in water (20 mol%). Low chemical yield was accounted for due to the low aldehyde solubility in water, but the enantioselectivity remained unchanged. The catalytic system could be 85% recovered with extractions and reused twice upon pretreatment [88].

33. Structures of catalysts 71 and 72. its solubility in water, allowing an easier way to achieve the catalyst recovery. The recovered polymer catalyst 71 (Fig. 33) showed good activity and selectivity. Weberskirch et al. built a self-assembled nanoreactor to perform the HKR of aromatic epoxides in pure water. The Co(III)-salen complex was anchored to an amphyphilic copolymer that formed micellar structures in water. The local high concentration of catalyst and the reasonable low concentration of water inside the micellar reactor allowed for the resolution of several types of aromatic epoxides with excellent enantioselectivitites (up to 51% conversion, 99% ee of epoxide, 96% ee of diol).

24. Structure of self-supported polymeric Aza-BOX catalyst 56. 16. Desymmetrization of 1,2-diols with copper- and polymer-supported aza-BOX. with this catalyst rose to 90% ee and its reutilization reached nine consecutive cycles [102]. In 2008, the application of the self-supported polymeric Aza-BOX catalyst 56 (Fig. 24) in the cyclopropanation of styrene (which curiously behaved as a heterogeneous and homogeneous catalyst) was reported. During the catalysis, the heterogeneous polymer becomes soluble, perhaps due to substrateinduced depolymerization and, at the end of the reaction, it precipitates.

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Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications by Michelangelo Gruttadauria


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